Rare or Uncommon Cancers: Where tissue-specific guidelines are limited and broad genomic insight is critical

Precision Reclassification and Targeted Intervention in Advanced Hepatocellular Carcinoma

Patient Profile:

• Age/Sex: 66-year-old male with chronic hepatitis B.
• Diagnosis: Advanced hepatocellular carcinoma (HCC) 
with multifocal liver lesions and lung metastases
mediastinal mass with no clear primary lesion.
• Clinical Course: Initial stable disease, now showing 
progression with new lung nodules.


Problem:

• Disease progression despite standard ICI + 
anti-VEGF combo.
• Need to identify molecular drivers and potential 
resistance mechanisms for salvage therapy.
• Histology is moderately differentiated, but tumor 
biology remains unclear