Clinical History & Chronological Summary
- Diagnosis: 50 y/ female diagnosed with poorly differentiated squamous cell carcinoma of cervix
- Initial Treatment: Initially treated with chemotherapy, brachytherapy, radiotherapy. Later, disease recurrence with multiple
nodal mets -> Pac+Carbo+Bev. Further progression, treated with Gem+Nab-Pac. - Further evaluation: Presently on Pem+Carbo+ZA. Comprehensive molecular profiling via OncoIndx Liquid Biopsy to understand
molecular cause for recurrence and aggressiveness and identify possible treatment resistance and directives
Clinical Challenges
- Recurrent, metastatic disease: Initial squamous cell carcinoma of cervix treated with definitive chemoradiation involving multiple nodal metastases, indicating systemic relapse and need for dynamic disease monitoring
- Heavily pretreated setting raises concern for evolving resistance clones and limited tissue access
- Recent Pem exposure in a low-TMB/MSS tumour raises concerns regarding sustained immunotherapy efficacy, thereby warranting serial ctDNA assessment to detect emergent targetable alterations or resistance-conferring variants.