Summary
Circulating tumor cell (CTC) analysis demonstrated significant clinical relevance in treatment-naïve oral squamous cell carcinoma (OSCC) patients. Elevated CTC burden in peripheral blood was linked to aggressive tumor biology, increased metastatic potential, and advanced disease stage. The study highlights the value of liquid biopsy–based CTC profiling as a minimally invasive approach for identifying high-risk patients. Quantitative CTC assessment enables early risk stratification and supports personalized treatment planning. Additionally, longitudinal monitoring of CTC levels provides real-time insights into disease progression and therapeutic response, reinforcing its role in precision oncology and clinical decision-making.
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Key Findings:-
- CTC presence is strongly linked to poor overall survival in treatment-naïve OSCC patients.
- Higher CTC counts indicate increased metastatic risk and disease aggressiveness.
- CTC enumeration enables early identification of high-risk patient subgroups.
- Liquid biopsy–based CTC profiling supports non-invasive prognostic evaluation.
- CTC dynamics can inform treatment strategy optimization and clinical management.