Co-Morbidities: Obesity, Hypertension, Type 2 diabetes presented with intermittent postmenopausal bleeding.
Initial Diagnosis: Transvaginal ultrasound revealed a heterogeneous endometrial thickening of 16mm, and endometrial
biopsy confirmed high-grade (HG) endometrioid carcinoma.
Clinical Challenges
Traditional Diagnostic Workflow
Delayed Diagnosis
/ Tissue Exhaustion
POLE-mutant status
justifies treatment
de-escalation and
confers excellent
prognosis
Morphology based classification (high-grade) often leads to overtreatment of cases
where molecular classification recommends de-escalationx