Single circulating tumor cell (sCTC) isolation from 30 metastatic cancer patients (lung, hepatocellular carcinoma) using the OncoRADAR live-cell capture platform without cell fixation
sCTCDNA vs. ctDNA comparison via bar graph shows OncoRADAR detected clinically significant mutations in 20% of patients where ctDNA returned No Mutation Detected (NMD)
Whole genome amplification and CGP performed on individual CTCs using degenerate primer-based PCR and targeted hybrid-capture with the Oncolndx 1080-gene panel
MATH score scatter plot demonstrates tumor mutational heterogeneity across sCTCs from lung cancer patients, highlighting intratumor diversity not detectable by ctDNA
Clonal evolution diagram of a hepatocellular carcinoma case illustrates 5 CTC clusters and 3 single CTCs revealing molecular divergence from the original progenitor clone
Actionable resistance variants identified include EGFR p.E746_A750 deletion and distinct AKT1/AKT2 amplification subclones — resistance mechanisms missed by ctDNA in EGFR-targeted therapy patients